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People and Labs of the CIRM CESCG

The CESCG funds projects at universities and research institutes across California. These projects were intended to interogate a few different broad subjects such as neurobiology, cardiac biology, blood stem cells and therapeutics, and the molecular regulators of stem cells.

A list of publications funded by the CESCG and written by participating labs can be found on our CESCG Publications page.

Co-Directors

Joseph Ecker, PhD
Professor and Director of Salk Genomic Analysis Laboratory
Howard Hughes Medical Institute - Gordon and Betty Moore Foundation Investigator
Salk International Council Chair in Genetics

Michael Snyder, PhD
Professor & Chair of Genetics at Stanford University
Director of the Stanford Center for Genomics & Personalized Medicine.

Labs and Principal Investigators

Kristin Baldwin, PhD
Scripps Research Institute, San Diego
The Baldwin lab is studying a matched set of induced pluripotent stem cell (iPSC) lines from patients with cardiovascular disease.

Benoit Bruneau, PhD
University of California, San Francisco
The Bruneau lab is investigating transcriptomic and epigenetic analysis of iPSC-derived cardiomyocytes at four stages of differentiation.


Juan Carlos Izpisua Belmonte, PhD
Salk Institute for Biological Studies, La Jolla
The Belmonte lab is working to characterize the molecular dynamics of cells undergoing 4F-induced reprogramming in vivo in the mouse.

Neil Chi, MD, PhD
University of California, San Diego
The Chi lab is generating human cardiac stem cells and functional cardiomyocytes for cardiac and vascular regenerative repairs.


Michael F. Clarke, MD
Stanford University, Palo Alto
The Clarke lab is collaborating with the Quake lab in exploring chromatin landscapes.

Jacob Corn, PhD
University of California, Berkeley
The Corn lab is investigating fixing sickle cell anemia with CRISPR. Aim 1 of the Corn lab is to use RNA-seq to explore erythroid (red blood cell) maturation. Aim 2 is using boutique DNA-seq methods to investigate effects of CRISPR.


Gay Crooks, MD
University of California, Los Angeles
The Crooks Lab is working to create a comprehensive transcriptome and epigenome map of human hematopoetic stem cell (HSC) ontogeny by comparing human hematopoietic tissues and cells derived from embryonic stem cells (ESCs).

Guoping Fan, PhD
University of California, Los Angeles
The Fan lab is working on identifying convergent target genes and signaling pathways perturbed in human overgrowth syndrome.


Kelly Frazer, PhD
University of California, San Diego
The Frazer lab is focused on performing high-throughput phenotypic characterization of iPSC-derived cardiomyocytes from a diverse set of ethnicities to enable further genetic studies investigating the segregation of traits.

Daniel Geschwind, MD
University of California, Los Angeles
The Geschwind lab exploring how multiple distinct mutations lead to the convergent pathology of autism spectrum disorder. They are analyzing the iPSC organoids from the Pasca lab.


Kathy Jones, PhD
Salk Institute for Biological Studies, La Jolla
The Jones lab is investigating the role of transcriptional regulators Yap1 and P-TEFb in human embryonic stem cell differentiation towards cardiomyocytes.

Arnold Kriegstein, PhD
University of California, San Francisco
The Kriegstein lab is using single-cell RNA profiling to learn about the diverse population of cortical neurons.


Jeanne Loring, PhD
Scripps Research Institute, San Diego
The Loring lab is carrying out preclinical studies to develop an autologous cell therapy for Parkinson's disease.

Sergiu Pasca, MD
Stanford University, Palo Alto
The Pasca lab are growing brain organoids with neurological disorders including deletions, duplications and triplications of 16p11.2, Timothy syndrome, epilepsy and mental retardation limited to female (EFMR).


Stephen Quake, DPhil
Stanford University, Palo Alto
The Quake lab is working on characterizing cell subpopulations of healthy and pathological tissues of the brain and pancreas. He is also looking at gene and epigenetic properties of organ lineages to compare stem cell differentiation hierarchy to normal tissues to elucidate mechanisms of pathogenesis.

Jeremy Sanford, PhD
University of California, Santa Cruz
The Sanford lab is studying how alternative pre-mRNA splicing contributes to the regulation of gene expression and protein diversity.


Michael Snyder, PhD
Stanford University, Palo Alto
The Snyder lab is investigating drug response of hypertrophic cardiomyopathy (HCM), dialated cardiomyopathy (DCM), and healthy (control) donors with a comprehensive survey combining iPSC-cardiac differentiation, drug treatment and genomic and transcriptomic analysis.

Irv Weissman, MD, PhD
Stanford University, Palo Alto
The Weissman lab are researching how the human mesoderm is diversified into an array of therapeutically-relevant tissues, including bone, cartilage, skeletal muscle, heart, kidneys and blood.


Gene Yeo, PhD
University of California, San Diego
The Yeo lab is exploring how RNA localizes in certain parts of the cell, effecting differentiation, stress and neurodegeneration, particularly with regards to ALS (amytrophic lateral sclerosis).

Data Coordination and Management Group

Josh Stuart
University of California, Santa Cruz
Head of of the Data Coordination and Management Group at UCSC.

Jim Kent
University of California, Santa Cruz
In charge of creating and maintaing the CESCG Stem Cell Hub at UCSC.


Galt Barber
University of California, Santa Cruz
Software engineer

Jonathan Casper
University of California, Santa Cruz
Software engineer

Max Haeussler
University of California, Santa Cruz
Software engineer

Clay Fischer
University of California, Santa Cruz
Project manager, Data wrangler


Paris Nejad
University of California, Santa Cruz
Data wrangler

Matthew Speir
University of California, Santa Cruz
Quality assurance

Chris Villarreal
University of California, Santa Cruz
Data wrangler

Other CESCG Staff at Salk and Stanford

Caesar Barragan
Salk Institute for Biological Studies, La Jolla
Research assistant

Roas G. Gomez Castanon
Salk Institute for Biological Studies, La Jolla
Research assistant

Manoj Hariharan
Salk Institute for Biological Studies, La Jolla
Staff scientist

Yupeng He
Salk Institute for Biological Studies, La Jolla
Graduate student


Ramesh Nair
Stanford University, Palo Alto
Acting Associate Director of Bioinformatics at the Stanford Center for Genomics and Personalized Medicine (SCGPM)

Joseph Nery
Salk Institute for Biological Studies, La Jolla
Research assistant