People and Labs of the CIRM CESCG

The CESCG funds projects at universities and research institutes across California. These projects were intended to interrogate a few different broad subjects such as neurobiology, cardiac biology, blood stem cells and therapeutics, and the molecular regulators of stem cells.

A list of publications funded by the CESCG and written by participating labs can be found on our CESCG Publications page.

Co-Directors
Joseph Ecker, PhD

Lab website

  • Professor and Director of Salk Genomic Analysis Laboratory
  • Howard Hughes Medical Institute - Gordon and Betty Moore Foundation Investigator
  • Salk International Council Chair in Genetics
Michael Snyder, PhD

Lab website

  • Professor & Chair of Genetics at Stanford University
  • Director of the Stanford Center for Genomics & Personalized Medicine
Labs and Principal Investigators
Kristin Baldwin, PhD

Lab website

  • Scripps Research Institute, San Diego
  • The Baldwin lab is studying a matched set of induced pluripotent stem cell (iPSC) lines from patients with cardiovascular disease.
Benoit Bruneau, PhD

Lab website

  • University of California, San Francisco
  • The Bruneau lab is investigating the transcriptomicr and epigenetic landscape of iPSC-derived cardiomyocytes at four stages of differentiation.
Juan Carlos Izpisua Belmonte, PhD

Lab website

  • Salk Institute for Biological Studies, La Jolla
  • The Belmonte lab is working to characterize the molecular dynamics of cells undergoing 4F-induced reprogramming in vivo in the mouse.

Neil Chi, MD, PhD

Lab website

  • University of California, San Diego
  • The Chi lab is generating human cardiac stem cells and functional cardiomyocytes for cardiac and vascular regenerative repairs.
Michael F. Clarke, MD

Lab website

  • Stanford University, Palo Alto
  • The Clarke lab is collaborating with the Quake lab in exploring chromatin landscapes.
Jacob Corn, PhD

Lab website

  • University of California, Berkeley
  • The Corn lab is investigating fixing sickle cell anemia with CRISPR. Aim 1 of the Corn lab is to use RNA-seq to explore erythroid (red blood cell) maturation. Aim 2 is using boutique DNA-seq methods to investigate effects of CRISPR.

Gay Crooks, MD

Lab website

  • University of California, Los Angeles
  • The Crooks Lab is working to create a comprehensive transcriptome and epigenome map of human hematopoetic stem cell (HSC) ontogeny by comparing human hematopoietic tissues and cells derived from embryonic stem cells (ESCs).
Guoping Fan, PhD

Lab website

  • University of California, Los Angeles
  • The Fan lab is working on identifying convergent target genes and signaling pathways perturbed in human overgrowth syndrome.
Kelly Frazer, PhD

Lab website

  • University of California, San Diego
  • The Frazer lab is focused on performing high-throughput phenotypic characterization of iPSC-derived cardiomyocytes from a diverse set of ethnicities to enable further genetic studies investigating the segregation of traits.

Daniel Geschwind, MD

Lab website

  • University of California, Los Angeles
  • The Crooks Lab is working to create a comprehensive transcriptome and epigenome map of human hematopoetic stem cell (HSC) ontogeny by comparing human hematopoietic tissues and cells derived from embryonic stem cells (ESCs).
Kathy Jones, PhD

Lab website

  • Salk Institute for Biological Studies, La Jolla
  • The Jones lab is investigating the role of transcriptional regulators Yap1 and P-TEFb in human embryonic stem cell differentiation towards cardiomyocytes.
Arnold Kriegstein, PhD

Lab website

  • University of California, San Francisco
  • The Kriegstein lab is using single-cell RNA profiling to learn about the diverse population of cortical neurons.

Jeanne Loring, PhD

Lab website

  • Scripps Research Institute, San Diego
  • The Loring lab is carrying out preclinical studies to develop an autologous cell therapy for Parkinson's disease.
Sergiu Pasca, MD

Lab website

  • Stanford University, Palo Alto
  • The Pasca lab is growing brain organoids with neurological disorders including deletions, duplications and triplications of 16p11.2, Timothy syndrome, epilepsy and mental retardation limited to female (EFMR).
Stephen Quake, DPhil

Lab website

  • Stanford University, Palo Alto
  • The Quake lab is working on characterizing cell subpopulations of healthy and pathological tissues of the brain and pancreas. He is also looking at gene and epigenetic properties of organ lineages to compare stem cell differentiation hierarchy to normal tissues to elucidate mechanisms of pathogenesis.

Jeremy Sanford, PhD

Lab website

  • University of California, Santa Cruz
  • The Sanford lab is studying how alternative pre-mRNA splicing contributes to the regulation of gene expression and protein diversity.
Michael Snyder, PhD

Lab website

  • Stanford University, Palo Alto
  • The Snyder lab is investigating drug response of hypertrophic cardiomyopathy (HCM), dialated cardiomyopathy (DCM), and healthy (control) donors with a comprehensive survey combining iPSC-cardiac differentiation, drug treatment and genomic and transcriptomic analysis.
Irv Weissman, MD, PhD

Lab website

  • Stanford University, Palo Alto
  • The Weissman lab is working on identifying and characterizing the progression of discrete changes, genetic and epigenetic, that leads to the generation of cancer stem cells (CSCs) from a variety of blood and solid tissue cancers. They have found a single molecular event present in all cancers studied to date that protects them from macrophages of the innate immune system.

Gene Yeo, PhD

Lab website

  • University of California, San Deigo
  • The Yeo lab is exploring how RNA localizes in certain parts of the cell, effecting differentiation, stress and neurodegeneration, particularly with regards to ALS (amytrophic lateral sclerosis).
Data Coordination and Management Group
Josh Stuart, PhD

Lab website

  • University of California, Santa Cruz
  • Head of of the Data Coordination and Management Group at UCSC.
Jim Kent, PhD

Lab website

  • University of California, Santa Cruz
  • In charge of creating and maintaining the CESCG Stem Cell Hub at UCSC.

Galt Barber

  • University of California, Santa Cruz
  • Software engineer
Jonathan Casper

  • University of California, Santa Cruz
  • Software engineer
Max Haeussler

  • University of California, Santa Cruz
  • Software engineer
Clay Fischer

  • University of California, Santa Cruz
  • Project manager, Data wrangler

Paris Nejad

  • University of California, Santa Cruz
  • Data wrangler
Matthew Speir

  • University of California, Santa Cruz
  • Software quality assurance, Web design
William Sullivan

  • University of California, Santa Cruz
  • Data Wrangler
Chris Villarreal

  • University of California, Santa Cruz
  • Data Wrangler
Other CESCG Staff at Salk and Stanford
Cesar Barragan

  • Salk Institute for Biological Studies, La Jolla
  • Research assistant
Rosa G. Gomez Castanon

  • Salk Institute for Biological Studies, La Jolla
  • Research assistant
Manoj Hariharan, PhD

  • Salk Institute for Biological Studies, La Jolla
  • Staff scientist
Hassan Chaib, PhD

  • Stanford University, Palo Alto
  • Director of Laboratory Operations at SCGPM and GSSC

Yupeng He

  • Salk Institute for Biological Studies, La Jolla
  • Graduate student
Ramesh Nair, PhD

  • Stanford University, Palo Alto
  • Acting Associate Director of Bioinformatics at SCGPM
Joseph Nery

  • Salk Institute for Biological Studies, La Jolla
  • Research assistant